Beyond Antibiotics?
نویسندگان
چکیده
منابع مشابه
Clostridium difficile--beyond antibiotics.
In this decade, the prevention and control of Clostridium difficile infection in health care settings has become a global public health challenge. Infection rates have increased dramatically, and several large outbreaks associated with toxinotype III BI/NAP1/027 strains have been described.1 One of the major incongruities in the management of C. difficile infection is that antibiotics are the m...
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Biofilm-associated bacteria are less sensitive to antibiotics than free-living (planktonic) cells. Furthermore, with variations in the concentration of antibiotics throughout a biofilm, microbial cells are often exposed to levels below inhibitory concentrations and may develop resistance. This, as well as the irresponsible use of antibiotics, leads to the selection of pathogens that are difficu...
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Dysregulation of the innate immune system drives lung injury and its systemic sequelae due to breakdown of vascular barrier function, harmful hyperinflammation and microcirculatory failure, which contribute to the unfavourable outcome of patients with severe pneumonia. A variety of promising therapeutic targets have been identified and numerous innovative therapeutic approaches demonstrated to ...
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M. Roxo-Rosa*, M. Oleastro and F. F. Vale Center for Biodiversity, Functional & Integrative Genomics (BioFIG), Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016, Lisboa, Portugal Departamento de Genética Humana, Instituto Nacional Saúde Dr. Ricardo Jorge, Av. Padre Cruz, 1649-016 Lisboa, Portugal Departamento de Doenças Infeciosas, Instituto Nacional Saúde Dr. Ricardo Jorge,...
متن کاملInhaled antibiotics beyond aminoglycosides, polymyxins and aztreonam: A systematic review.
We sought to evaluate published evidence regarding clinical or microbiological outcomes related to the use of inhaled antibiotics other than aminoglycosides, polymyxins and aztreonam. A systematic search of PubMed and Scopus databases as well as bibliographies of eligible articles was performed. In total, 34 eligible studies were identified. Among several inhaled β-lactams, ceftazidime was used...
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ژورنال
عنوان ژورنال: Canadian Journal of Infectious Diseases and Medical Microbiology
سال: 2006
ISSN: 1712-9532
DOI: 10.1155/2006/435962